Publications

Methotrexate interacts with gut microbiota
We found that methotrexate (MTX) can affect bacteria and, in doing so, may contribute to less inflammation in mouse models. MTX is also metabolized by human gut bacteria. These findings may explain why patients vary in their response to MTX.

2024

Nayak RR, Orellana DA. The impact of the human gut microbiome on the treatment of autoimmune disease. Immunol Rev. 2024;00:1-24. doi:10.1111/imr.13358. pdf.

Karin C Wu, Kathryn E McCauley, Susan V Lynch, Renuka R Nayak, Nicole J King, Sheena Patel, Tiffany Y Kim, Katherine Condra, Doug Fadrosh, Dat Nguyen, Din L Lin, Kole Lynch, Stanley J Rogers, Jonathan T Carter, Andrew M Posselt, Lygia Stewart, Anne L Schafer. Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy. Journal of Bone and Mineral Research. 2024; 39(2): 95-105. pdf.

2023

Escalante V, Nayak RR, Noecker C, Babdor J, Spitzer M, Deutschbauer AM, Turnbaugh PJ (2023). Simvastatin induces human gut bacterial cell surface genes. Mol Microbiol. 2023;00:1–15. pdf.


Bustion AE, Nayak RR, Agrawal A, Turnbaugh PJ, Pollard KS (2023). "SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations." Elife 2023 Jun 12;12:e82401. pdf.

2022

Nayak, R. R. (2022). "Fanning the flames of autoimmunity: the microbiome in rheumatic disease." Arthritis & Rheumatology 74 (4), 549-552. pdf

Alexander, M., Q. Y. Ang, R. R. Nayak, A. E. Bustion, M. Sandy, B. Zhang, V. Upadhyay, K. S. Pollard, S. V. Lynch and P. J. Turnbaugh (2022). "Human gut bacterial metabolism drives Th17 activation and colitis." Cell Host & Microbe 30 (1) 17-30. pdf

2021

Lam, K. N., P. Spanogiannopoulos, P. Soto-Perez, M. Alexander, M. J. Nalley, J. E. Bisanz, R. R. Nayak, A. M. Weakley, F. B. Yu and P. J. Turnbaugh (2021). "Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome." Cell Rep 37(5): 109930. pdf

Nayak, R. R. (2021). "Western Diet and Psoriatic-Like Skin and Joint Diseases: A Potential Role for the Gut Microbiota." J Invest Dermatol 141(7): 1630-1632. pdf

Nayak, R. R., M. Alexander, I. Deshpande, K. Stapleton-Gray, B. Rimal, A. D. Patterson, C. Ubeda, J. U. Scher and P. J. Turnbaugh (2021). "Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation." Cell Host Microbe 29(3): 362-377 e311. pdf

2020

Scher, J. U., R. R. Nayak, C. Ubeda, P. J. Turnbaugh and S. B. Abramson (2020). "Pharmacomicrobiomics in inflammatory arthritis: gut microbiome as modulator of therapeutic response." Nat Rev Rheumatol 16(5): 282-292.

Artacho, A.*, S. Isaac*, R. Nayak*, A. Flor-Duro, M. Alexander, I. Koo, J. Manasson, P. B. Smith, P. Rosenthal, Y. Homsi, P. Gulko, J. Pons, L. Puchades-Carrasco, P. Izmirly, A. Patterson, S. B. Abramson, A. Pineda-Lucena, P. J. Turnbaugh, C. Ubeda and J. U. Scher (2020). "The Pre-treatment Gut Microbiome is Associated with Lack of Response to Methotrexate in New Onset Rheumatoid Arthritis." Arthritis Rheumatol. *equal contribution. pdf.

2016

Nayak, R. R. and P. J. Turnbaugh (2016). "Mirror, mirror on the wall: which microbiomes will help heal them all?" BMC Med 14: 72.

Mok, A., O. Solomon, R. R. Nayak, P. Coit, H. L. Quach, J. Nititham, A. H. Sawalha, L. F. Barcellos, L. A. Criswell and S. A. Chung (2016). "Genome-wide profiling identifies associations between lupus nephritis and differential methylation of genes regulating tissue hypoxia and type 1 interferon responses." Lupus Sci Med 3(1): e000183.

2014

Nayak, R. R., W. E. Bernal, J. W. Lee, M. J. Kearns and V. G. Cheung (2014). "Stress-induced changes in gene interactions in human cells." Nucleic Acids Res 42(3): 1757-1771.

2010

Dombroski, B. A.*, R. R. Nayak*, K. G. Ewens, W. Ankener, V. G. Cheung and R. S. Spielman (2010). "Gene expression and genetic variation in response to endoplasmic reticulum stress in human cells." Am J Hum Genet 86(5): 719-729. *equal contribution

Cheung, V. G., R. R. Nayak, I. X. Wang, S. Elwyn, S. M. Cousins, M. Morley and R. S. Spielman (2010). "Polymorphic cis- and trans-regulation of human gene expression." PLoS Biol 8(9).

2009

Nayak, R. R., M. Kearns, R. S. Spielman and V. G. Cheung (2009). "Coexpression network based on natural variation in human gene expression reveals gene interactions and functions." Genome Res 19(11): 1953-1962.

2006

Wallenfang, M. R., R. Nayak and S. DiNardo (2006). "Dynamics of the male germline stem cell population during aging of Drosophila melanogaster." Aging Cell 5(4): 297-304.